ea0029p1358 | Pituitary Basic | ICEECE2012
Cassarino M.
, Sesta A.
, Cavagnini F.
, Pecori Giraldi F.
Corticotropin-releasing hormone (CRH) is known to be produced and secreted by normal rat corticotropes and to contribute in a paracrine manner to POMC synthesis and ACTH secretion in these cells. The regulation of intrapituitary CRH however still has to be clarified.Aim: This study was to establish whether CRH gene expression can be measured in rat pituitaries in vitro and whether CRH modulates its own gene expression within the pitu...